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Old 02-07-10, 09:02 PM
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Default Scientists discover what makes us live longer

From the Independent

Scientists discover what makes us live longer

New test unlocks secrets of life expectancy by predicting which of us will reach 100

By Steve Connor
Science Editor
Friday, 2 July 2010


A genetic test has been developed that can predict whether someone is likely to live an extremely long life, but scientists have warned that society is still not ready for such predictions.

The test is based on a scan of a person's entire genome; so far it can predict whether someone is likely to live to 100 with an accuracy of 77 per cent. However, refinements to the test will improve its precision, raising the prospect that it could one day be used to predict whether someone is genetically predisposed to extreme longevity.

Commercial organisations are likely to market the test within a few years. But the scientists behind the research warn that there should be a public debate on the ethical implications behind such testing.

Researchers developed the test by analysing the genomes of 1,055 centenarians from different parts of the world and comparing slight variations in their DNA with the genetic makeup of a set of people younger than 100. The scientists found that by concentrating on just 150 individual mutations in the human genome, they could predict with 77 per cent accuracy whether someone belonged to the group of centenarians. Although the test is still at a rudimentary stage, scientists said that they could foresee it being developed commercially within a few years to identify people with an inherited predisposition to live a long life that is likely, until the final years, to be largely free of age-related disorders such as cancer and heart disease.

Thomas Perls of the Boston University School of Medicine, who led the study published in the journal Science, said the aim of the research was to understand the genetic reasons why some people live longer than others despite having similar lifestyles.

"We embarked on the study to understand the genetics of exceptional longevity," Professor Perls said. "Clearly we realise that this is a very complex genetic puzzle. Exceptional longevity is not the vacuous entity that some people make it out to be. This really opens the door to understanding the genetic and lifestyle determinants of longevity."

Professor Perls said that a predictive accuracy of 77 per cent is "fairly unprecedented" and there is nothing to stop biotechnology companies from using this information, which is now freely available in the public domain, to develop commercial tests for extreme longevity. But he warned: "I for one don't think we're ready from a social point of view, but I think that won't stop companies from trying to market this."

The scientists found that 90 per cent of the centenarians in the study possessed a definite "genetic signature" of extreme longevity, denoted by the particular combination of genetic mutations they carried. The researchers also found that 45 per cent of the oldest centenarians – those over the age of 110 – had a genetic signature with the highest proportion of longevity-associated mutations.

Professor Perls said: "These genetic signatures are a new advance towards personalised genomics and predictive medicine, where this analytic method may prove to be generally useful in prevention and screening of numerous diseases, as well as in the tailored uses of medications."

Extreme longevity is known to have a strong genetic component as it tends to run in families, though a healthy lifestyle is also important. The team concluded: "This prediction is not perfect, and although it may improve with better knowledge of the variations in the human genome, its limitations confirm that environmental factors, for example lifestyle, also contribute in important ways to the ability of humans to survive to very old ages."

Scientists have tried for decades to find the genetic basis of human longevity by investigating the genes that influence ageing in a range of lifeforms, from simple yeast cells to laboratory strains of mice.

In 2008, scientists managed to extend the life of yeast cells tenfold by altering their genetic make-up and putting them on a calorie-restricted diet, which is widely observed to increase longevity across the animal kingdom. The search of similar "ageing genes" in humans, however, has had limited success.

But following the completion of the mapping of the human genome, it is now possible for scientists to scan the entire DNA of a person to identify the many different inherited traits that may be linked with a particular condition, whether it is an age-related illness such as coronary heart disease or cancer, or extreme longevity.

Paola Sebastiani, who worked with Professor Perls on the study, said: "The methodology we developed can be applied to other complex genetic traits, including Alzheimer's disease, Parkinson's, cardiovascular disease and diabetes."
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Old 02-07-10, 09:05 PM
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I am sure that insurance companies will be very interested in this test to compute life insurance premiums and retirement income.
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Old 03-07-10, 01:34 PM
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Suppose that every child was given a genetic test around the age of 12 or 13 that could predict with moderate accuracy how long, barring accidents they might live.

How might that affect society? If my parents, who married in 1941, had known that my father, who was a year older than my mother would die at 72 and she would survive until 81, would that have changed the course of their lives?
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Old 03-07-10, 05:40 PM
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Hmmm...

And they give fortune tellers a hard time.

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Old 05-07-10, 02:01 AM
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They could just look at people's bank accounts.

Poor in UK dying 10 years earlier than rich, despite years of government action | Society | The Guardian


Poor in UK dying 10 years earlier than rich, despite years of government action


Department of Health and NHS criticised for making too little progress on tackling key barometer of inequality

Denis Campbell, health correspondent
The Guardian, Friday 2 July 2010


The life expectancy gap between rich and poor people in England is widening, despite years of government and NHS action, a hard-hitting National Audit Office report reveals today.

Extensive efforts have failed to reduce the wide differential, which can still be 10 years or more depending on socio-economic background, says the public spending watchdog. While life expectancy has risen generally, it is increasing at a slower rate for England's poorest citizens.

In Blackpool, for example, men live for an average of 73.6 years, which is 10.7 fewer than men in Kensington and Chelsea in central London, who reach 84.3 years. Similarly, women in the Lancashire town typically die at 78.8 years – 10.1 years earlier than those in the London borough, who reach an average 89.9.

The gap in life expectancy between government-designated areas of high deprivation and the national average has continued to widen, so Labour's aim of reducing it by 10% will not be met, the NAO concludes. The failure to meet the target has cost an estimated 3,300 lives.

The report criticises the Department of Health and the NHS for making too little progress to tackle this key barometer of inequality. Although the DoH set a target in 2000 to reduce health inequalities and published a strategy in 2003, real NHS action did not begin until 2006, it says.

"The Department of Health has made a concerted effort to tackle a very difficult and long-standing problem," said Amyas Morse, head of the NAO.

"However, it was slow to take action and health inequalities were not a top priority for the NHS until 2006."

The service was also slow to apply three key policies, including giving more poor people drugs to reduce their blood pressure or cholesterol level. "These have yet to be adopted on the scale required to close the inequalities gap," the NAO said.

The report also highlights a continuing lack of GPs in poor areas with high health need, despite shortages having been identified as a problem in 2000. It is also unclear whether an extra £230 a head spent in some areas to improve health outcomes has had any real impact.

Professor Alan Maryon-Davis, president of the UK Faculty of Public Health, said the disparities showed the inequality of English society. "If we see ourselves as a civilised society, these gaps are an indication of unfairness, which shouldn't be there, and is an unfairness which costs lives, damages people's health and will eventually be a huge burden on the NHS if they aren't tackled," he said.

But the NAO report did contain good news about improvements in the health of England's poorest citizens, he added. "The health of the people in the poorest areas is going in the right direction – that's good news. We shouldn't regard that as a failure. But the bulk of the population are improving their health at a faster rate." He urged ministers to resist any temptation to cut spending on health inequalities in the tough financial climate.

Anne Milton, the public health minister, emphasised the government's belief in health equality. "Everyone should have the same opportunities to lead a healthy life no matter where they live. We want the public's health to be at the very heart of all we do, not just in the NHS but across government," she said.

"This report shows that efforts have been made to address health inequalities but that more needs to be done to tackle the deep-rooted social problems that cause ill-health. I want to see the NHS, doctors and local government acting at the right time to improve the health of those who need it most."

The NHS Confederation, which represents most health service organisations, admitted that more progress was needed. Jo Webber, its deputy policy director, said: "The NHS and its partners, especially in local government, have a responsibility to help stop people falling into and continuing in ill-health rather than picking up the pieces when it may be too late. Encouraging improved health requires a focus on all aspects of society, including economic inequality, and quality of life in early years."

Tammy Boyce, of the King's Fund health thinktank, said the NHS could only achieve so much. "Tackling health inequalities is not a task for the NHS alone. It requires a co-ordinated, long-term commitment across government to address the wider causes of ill health such as poverty and poor housing," she said.

"The first test of whether the coalition government is likely to succeed where the previous government failed will come in this autumn's spending review. It is vital that cross-cutting issues like health inequalities are not overlooked in the scramble to deliver spending cuts on a department-by-department basis."

Michelle Mitchell, charity director at Age UK, said the big gap in life expectancy had to be tackled in the light of the government's intention to increase the age at which people can draw the state pension. "With a 13-year disparity in life expectancy between different areas of the country, it's shocking that primary care trusts are still failing to use simple and effective treatments to help tackle the problem.

"This report follows the government's announcement last week to raise the state pension age further and faster, which will hit those with a shorter life expectancy in the poorest areas of Britain hardest," she said. "In this context, tackling health inequalities is more urgent than ever and the government must set ambitious targets to close the yawning life expectancy divide."
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Old 05-07-10, 06:00 AM
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Yep! You an find similar statistics from the U.S.

African Americans living in Mississippi die on average 15 years younger than Asian Americans living in California ... for purely economic reasons.
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